Donepezil – QT prolongation and torsades de pointes

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Dothiepin, Qt Prolongation and Torsades De Pointes

A case is reported of electrocardiographic QT prolongation that was presumbty familial in origin. Torsades de points developed in association with the use ofdothinepin, despite the pmscription of a low dose of this drug.

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Torsades de pointes (TdP)-an uncommon but life-threatening polymorphic ventricular tachycardia-is almost always drug induced. The authors describe the causes, risk factors, symptoms, diagnosis, and treatment of TdP.

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Drug Induced Qt Prolongation and Torsades De Pointes

Correspondence to: Dr Yee Guan Yap, Department of Cardiological Sciences, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK; [email protected] _________________________ I n 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he termed ‘‘torsades de pointes’’ (TdP). w2 The word ‘‘torsades’’ refers to an ornam...

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Probucol-induced QT prolongation and torsades de pointes.

Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventri...

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ژورنال

عنوان ژورنال: Clinical Medicine

سال: 2019

ISSN: 1470-2118,1473-4893

DOI: 10.7861/clinmedicine.19-2-189